Oxalyl chloride → 4-[4-(1-Methylethyl)phenyl]-2-thiazolecarbonyl chloride

HRID 1162602Notes

Reaction equation

HRID 1162602 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([C:15]([OH:17])=O)[S:13][CH:14]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].C(Cl)(=O)C([Cl:21])=O>C(Cl)(Cl)Cl>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([C:15]([Cl:21])=[O:17])[S:13][CH:14]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 207501804-[4-(Propan-2-yl)phenyl]-1,3-thiazole-2-carboxylic acid

Product 1

HCID 860798104-[4-(1-Methylethyl)phenyl]-2-thiazolecarbonyl chloride

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

4-(4-Isopropyl-phenyl)-thiazole-2-carbonyl chloride was prepared by refluxing a mixture of 4-(4-Isopropyl-phenyl)-thiazole-2-carboxylic acid (50 mg) and oxalyl chloride (300 μl) in chloroform (5 mL). After 3 h, the volatiles were evaporated and the residue was dried under high vacuum to provide the acid chloride (50 mg).

Workup

  1. temperatureby refluxing
  2. customthe volatiles were evaporated
  3. customthe residue was dried under high vacuum

Sources & evidence

ORD record
ord-52b0ee15dd494030b44d3c5b9a598395
Source dataset
uspto-grants-2010_10
Patent number
US07820704B2

Reaction notes

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