Methyl 4-aminocyclohexanecarboxylate → HCID 86601765, compound

HRID 1162604Notes

Reaction equation

[CH3:1][O:2][C:3]([CH:5]1[CH2:10][CH2:9][CH:8]([NH2:11])[CH2:7][CH2:6]1)=[O:4].C([N:29]=[C:30]=[S:31])(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O>>[CH3:1][O:2][C:3]([CH:5]1[CH2:10][CH2:9][CH:8]([NH:11][C:30]([NH2:29])=[S:31])[CH2:7][CH2:6]1)=[O:4]

Participants

Reactant 2

HCID 422580Methyl 4-aminocyclohexanecarboxylate

HCID 4154759Fmoc isothiocyanate

Product 1

HCID 86601765HCID 86601765, compoundYield 26.7%

Procedure

4-Thioureido-cyclohexanecarboxylic acid methyl ester (150 mg) compound was prepared following general procedure D using 4-Amino-cyclohexanecarboxylic acid methyl ester (500 mg, 11.0 mmol), and Fmoc-isothiocyanate (730 mg). Purification: (Silica gel, ethyl acetate/hexane 1:1). LCMS m/z: 217.0 (M+1)+.

Workup

customPurification

Sources & evidence

ORD record: ord-3e6f3d02870c49e1bb2a9e6d6506e51e
Source dataset: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07820704B2

Reaction notes

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