5-Chloro-2-thiophenecarboxylic acid → HCID 58748323, compound

HRID 1162607Notes

Reaction equation

HRID 1162607 reaction equation
Cl.Cl.[CH2:3]([O:5][C:6](=[O:14])[CH2:7][N:8]1[CH2:12][CH2:11][C@@H:10]([NH2:13])[CH2:9]1)[CH3:4].[Cl:15][C:16]1[S:20][C:19]([C:21](O)=[O:22])=[CH:18][CH:17]=1>>[CH2:3]([O:5][C:6](=[O:14])[CH2:7][N:8]1[CH2:12][CH2:11][C@@H:10]([NH:13][C:21]([C:19]2[S:20][C:16]([Cl:15])=[CH:17][CH:18]=2)=[O:22])[CH2:9]1)[CH3:4]

Participants

3

Reactant 2

HCID 950485-Chloro-2-thiophenecarboxylic acidHCID 68646554HCID 68646554, compound

Product 1

HCID 58748323HCID 58748323, compound

Procedure

1.3 Using general method D, ((R)-3-amino-pyrrolidin-1-yl)-acetic acid ethyl ester dihydrochloride was coupled with 5-chlorothiophene-2-carboxylic acid to give {(R)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-pyrrolidin-1-yl}-acetic acid ethyl ester. Off-white amorphous solid. MS 317.0 ([M+H]+)

Sources & evidence

ORD record
ord-1a4a5a08604b45389049156c8d032f5a
Source dataset
uspto-grants-2010_10
Patent number
US07820699B2

Reaction notes

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