4-Chlorobenzoic Acid → HCID 58748235, compound

HRID 1162609Notes

Reaction equation

HRID 1162609 reaction equation
Cl.Cl.[CH2:3]([O:5][C:6](=[O:14])[CH2:7][N:8]1[CH2:12][CH2:11][C@@H:10]([NH2:13])[CH2:9]1)[CH3:4].[Cl:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](O)=[O:21])=[CH:18][CH:17]=1>>[CH2:3]([O:5][C:6](=[O:14])[CH2:7][N:8]1[CH2:12][CH2:11][C@@H:10]([NH:13][C:20](=[O:21])[C:19]2[CH:23]=[CH:24][C:16]([Cl:15])=[CH:17][CH:18]=2)[CH2:9]1)[CH3:4]

Participants

3

Reactant 2

HCID 63184-Chlorobenzoic AcidHCID 68646554HCID 68646554, compound

Product 1

HCID 58748235HCID 58748235, compound

Procedure

5.1 Using general procedure D ((R)-3-amino-pyrrolidin-1-yl)-acetic acid ethyl ester dihydrochloride (example 1.2) was coupled with 4-chlorobenzoic acid to give [(R)-3-(4-chloro-benzoylamino)-pyrrolidin-1-yl]-acetic acid ethyl ester. Solid. MS 311.3 ([M+H]+)<

Sources & evidence

ORD record
ord-a38c44e287b14ca6abbed9ad71b16520
Source dataset
uspto-grants-2010_10
Patent number
US07820699B2

Reaction notes

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