5-Chloro-2-thiophenecarboxylic acid → HCID 58748154, compound

HRID 1162610Notes

Reaction equation

HRID 1162610 reaction equation
[C:1]([N:8]1[CH2:12][CH2:11][C@@H:10]([NH2:13])[CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[Cl:14][C:15]1[S:19][C:18]([C:20](O)=[O:21])=[CH:17][CH:16]=1>>[C:4]([O:3][C:1]([N:8]1[CH2:12][CH2:11][C@@H:10]([NH:13][C:20]([C:18]2[S:19][C:15]([Cl:14])=[CH:16][CH:17]=2)=[O:21])[CH2:9]1)=[O:2])([CH3:7])([CH3:6])[CH3:5]

Participants

3

Reactant 2

HCID 950485-Chloro-2-thiophenecarboxylic acidHCID 854070(R)-(+)-1-Boc-3-aminopyrrolidine

Product 1

HCID 58748154HCID 58748154, compound

Procedure

6.1 Using general procedure D (R)-1-Boc-3-aminopyrrolidine was coupled with 5-chlorothiophene-2-carboxylic acid to give (R)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-pyrrolidine-1-carboxylic acid tert-butyl ester. Yellow solid. MS 329.3 ([M−H]−)

Sources & evidence

ORD record
ord-fc10926032fc490681aa72deeb2fa08e
Source dataset
uspto-grants-2010_10
Patent number
US07820699B2

Reaction notes

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