1-(1-Methyl-4-piperidinyl)piperazine → HCID 58748299, compound

HRID 1162619Notes

Reaction equation

HRID 1162619 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][CH:10]2[CH2:15][CH2:14][CH2:13][N:12]([CH2:16][C:17]([OH:19])=O)[CH2:11]2)=[O:8])=[CH:4][CH:3]=1.[CH3:20][N:21]1[CH2:26][CH2:25][CH:24]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[CH2:23][CH2:22]1>>[CH3:20][N:21]1[CH2:22][CH2:23][CH:24]([N:27]2[CH2:32][CH2:31][N:30]([C:17](=[O:19])[CH2:16][N:12]3[CH2:13][CH2:14][CH2:15][CH:10]([NH:9][C:7]([C:5]4[S:6][C:2]([Cl:1])=[CH:3][CH:4]=4)=[O:8])[CH2:11]3)[CH2:29][CH2:28]2)[CH2:25][CH2:26]1

Participants

3

Reactant 2

HCID 5663241-(1-Methyl-4-piperidinyl)piperazineHCID 58748275HCID 58748275, compound

Product 1

HCID 58748299HCID 58748299, compound

Procedure

Using general procedure D {3-[(5-chloro-thiophene-2-carbonyl)-amino]-piperidin-1-yl}-acetic acid (containing 2 mol equivalents of sodium chloride) was coupled with 1-(N-methyl-4-piperidyl)-piperazine to give 5-chloro-thiophene-2-carboxylic acid (1-{2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidin-3-yl)-amide. Off-white solid. 468.5 ([M+H]+)

Sources & evidence

ORD record
ord-b0fd31e80f204ee38f84909ae244b896
Source dataset
uspto-grants-2010_10
Patent number
US07820699B2

Reaction notes

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