1-(1-Methyl-4-piperidinyl)piperazine → HCID 58748299, compound

Participants

Reaction Steps

Using general procedure D {3-[(5-chloro-thiophene-2-carbonyl)-amino]-piperidin-1-yl}-acetic acid (containing 2 mol equivalents of sodium chloride) was coupled with 1-(N-methyl-4-piperidyl)-piperazine to give 5-chloro-thiophene-2-carboxylic acid (1-{2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidin-3-yl)-amide. Off-white solid. 468.5 ([M+H]+)

Provenance & Evidence