HCID 68646448, compound → HCID 11979006, compound

HRID 1162634Notes

Reaction equation

HRID 1162634 reaction equation
Cl.[OH:2][C@H:3]1[CH2:7][NH:6][CH2:5][C@@H:4]1[NH:8][C:9]([C:11]1[S:12][C:13]([Cl:16])=[CH:14][CH:15]=1)=[O:10].BrC([C:22]1[CH:27]=[CH:26][C:25]([N:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]2=[O:34])=[CH:24][C:23]=1[F:35])C(N)=O>CN(C=O)C>[F:35][C:23]1[CH:24]=[C:25]([N:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]2=[O:34])[CH:26]=[CH:27][C:22]=1[NH:8][C:9]([CH2:11][N:6]1[CH2:7][C@H:3]([OH:2])[C@@H:4]([NH:8][C:9]([C:11]2[S:12][C:13]([Cl:16])=[CH:14][CH:15]=2)=[O:10])[CH2:5]1)=[O:10]

Participants

4

Reactant 2

HCID 68646448HCID 68646448, compoundHCID 86608830HCID 86608830, compound

Product 1

HCID 11979006HCID 11979006, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

22.6 Using general procedure A with DMF as solvent 5-chloro-thiophene-2-carboxylic acid ((3S,4S)-4-hydroxy-pyrrolidin-3-yl)-amide hydrochloride was reacted with 2-bromo-[2-fluoro-4-(2-oxo-pyridin-1-yl)-phenyl]-acetamide to give 5-chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxy-pyrrolidin-3-yl)-amide. Light-yellow solid. MS 491.3 ([M+H]+)

Sources & evidence

ORD record
ord-8cda1686e12f4f4ba4ae5545478dbd33
Source dataset
uspto-grants-2010_10
Patent number
US07820699B2

Reaction notes

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