5-Chloro-1-benzofuran-2-carboxylic acid → HCID 58748253, compound

HRID 1162677Notes

Reaction equation

HRID 1162677 reaction equation
[NH2:1][CH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4]1.[Cl:15][C:16]1[CH:17]=[CH:18][C:19]2[O:23][C:22]([C:24](O)=[O:25])=[CH:21][C:20]=2[CH:27]=1>>[C:11]([O:10][C:8]([N:5]1[CH2:6][CH2:7][C@H:3]([CH2:2][NH:1][C:24]([C:22]2[O:23][C:19]3[CH:18]=[CH:17][C:16]([Cl:15])=[CH:27][C:20]=3[CH:21]=2)=[O:25])[CH2:4]1)=[O:9])([CH3:14])([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 9378385-Chloro-1-benzofuran-2-carboxylic acidHCID 1515152tert-Butyl (3R)-3-(aminomethyl)pyrrolidine-1-carboxylate

Product 1

HCID 58748253HCID 58748253, compound

Procedure

67.1 Using general procedure E, (R)-3-aminomethyl-1-N-tert-butoxycarbonyl-pyrrolidine was coupled with 5-chloro-benzofuran-2-carboxylic acid to give (R)-3-{[(5-chloro-benzofuran-2-carbonyl)-amino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester. White solid. MS377.3 ([M−H]−)

Sources & evidence

ORD record
ord-eea213876f3a4a37a2128f9118ffd1b3
Source dataset
uspto-grants-2010_10
Patent number
US07820699B2

Reaction notes

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