{(3S,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-methoxy-pyrrolidin-1-yl}-acetic acid ethyl ester → 2-(2-{(3S,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-methoxy-pyrrolidin-1-yl}-acetylamino)-6,7-dihydro-thiazolo[5,4-]pyridine-5-carboxylic acid tert-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	{(3S,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-methoxy-pyrrolidin-1-yl}-acetic acid ethyl ester	HCID 58748327	—
Reactant	2-Amino-6,7-dihydro-thiazolo[5,4]pyridine-5-carboxylic acid tert-butyl ester	HCID 86608840	—
Product	2-(2-{(3S,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-methoxy-pyrrolidin-1-yl}-acetylamino)-6,7-dihydro-thiazolo[5,4-]pyridine-5-carboxylic acid tert-butyl ester	HCID 86608839	—

Reaction Steps

94.1 In analogy to example 25.3 {(3S,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-methoxy-pyrrolidin-1-yl}-acetic acid ethyl ester (example 25.2) was reacted with 2-amino-6,7-dihydro-thiazolo[5,4]pyridine-5-carboxylic acid tert-butyl ester (CAS 365996-05-0) to give 2-(2-{(3S,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-methoxy-pyrrolidin-1-yl}-acetylamino)-6,7-dihydro-thiazolo[5,4-]pyridine-5-carboxylic acid tert-butyl ester as off-white solid. MS 556.3 ([M+H]+)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07820699B2
Source dataset	uspto-grants-2010_10
ORD ID	ord-27c1e994a6b54a89b36ed87eb2735d38
Source note	uspto-grants-2010_10