Trifluoroacetic acid → HCID 68647069, compound

HRID 1162730Notes

Reaction equation

HRID 1162730 reaction equation
[CH2:1]([O:3][C:4](=[O:20])[C:5]([N:7]1[CH2:11][CH2:10][CH:9]([NH:12]C(OC(C)(C)C)=O)[CH2:8]1)=[O:6])[CH3:2].[C:21]([OH:27])([C:23]([F:26])([F:25])[F:24])=[O:22]>C(Cl)Cl>[F:24][C:23]([F:26])([F:25])[C:21]([OH:27])=[O:22].[CH2:1]([O:3][C:4](=[O:20])[C:5]([N:7]1[CH2:11][CH2:10][CH:9]([NH2:12])[CH2:8]1)=[O:6])[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68646346HCID 68646346, compound

Product 1

HCID 68647069HCID 68647069, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

106.2 (3-tert-Butoxycarbonylamino-pyrrolidin-1-yl)-oxo-acetic acid ethyl ester (1.5 g) was dissolved in CH2Cl2 (7 ml) and TFA (7 ml) was added. The mixture was stirred at 25° C. for 3 h, evaporated to dryness to yield crude (3-amino-pyrrolidin-1-yl)-oxo-acetic acid ethyl ester trifluoroacetate as red brown oil (1.57 g). MS 187.3 ([M+H]+)

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-156fda16b58e485eb99a5e51b1423e7b
Source dataset
uspto-grants-2010_10
Patent number
US07820699B2

Reaction notes

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