HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 178440338, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | (S)-2-aminopropanamide hydrochloride | HCID 2775816 | — |
| Reactant | HCID 178440339 | HCID 178440339 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178440338 | HCID 178440338 | — |
Reaction Steps
500 mg of compound 46 and 145 mg of □-alaninamide hydrochloride are introduced into 10 ml of dichloromethane, and 0.8 ml of N,N-diisopropylethylamine, 215 mg of 1-hydroxybenzotriazole and 306 mg of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride are added. The solution is stirred for 12 h. The solution is concentrated and the crude product is purified by chromatography on silica gel (dichloromethane/methanol/glacial acetic acid 100:0:5→100:10:5). 440 mg of the desired compound 47 are obtained. C20H25N5O3 (383.5); MS (ESI+): 384.2 (M+H)+, tR=3.58 min (Gradient 3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820804B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-44efb37126b64e7e915ad91c0ad0570e |
| Source note | uspto-grants-2010_10 |