(-)-Benzyl (R)-glycidyl ether → HCID 57557907, compound

HRID 1162915Notes

Reaction equation

HRID 1162915 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[C:19]([F:22])([F:21])[F:20])[NH:8][C:9]2=[O:12])=[CH:4][CH:3]=1.[CH2:23]([O:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C@@H:24]1[O:26][CH2:25]1>>[CH2:28]([O:27][CH2:23][C@H:24]([OH:26])[CH2:25][NH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[C:19]([F:22])([F:20])[F:21])[NH:8][C:9]2=[O:12])=[CH:4][CH:3]=1)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 159746(-)-Benzyl (R)-glycidyl etherHCID 231567387-amino-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one

Product 1

HCID 57557907HCID 57557907, compound

Procedure

Using the 7-amino-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one obtained in step C of Example 1-1 and (R)— benzyl glycidyl ether as raw materials, the captioned compound was synthesized by a reaction similar to step A of Example 2-1.

Workup

  1. customthe captioned compound was synthesized by a reaction similar to step A of Example 2-1

Sources & evidence

ORD record
ord-fee47de7c69b46ed9c8e9462869fb177
Source dataset
uspto-grants-2010_10
Patent number
US07820693B2

Reaction notes

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