反应详情

The 7-bromo-3-(2-methylsulfonylphenyl)-2H-isoquinolin-1-one (7 mg, 0.019 mmol) prepared in step A, copper iodide (I) (3.5 mg, 0.019 mmol), (R)-5-hydroxymethyloxazolidin-2-one (2.2 mg, 0.019 mmol), and potassium carbonate (5.3 mg, 0.039 mmol) were suspended in 1,4-dioxane (0.5 ml). Thereafter, N,N′-dimethylethylenediamine (0.01 ml, 0.093 mmol) was added to the suspension. The obtained mixture was stirred under heating to reflux overnight. The reaction solution was cooled to a room temperature. A saturated ammonium chloride aqueous solution was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate, and the solvent was distilled away under reduced pressure. The obtained residue was purified by silica gel column chromatography (methylene chloride:methanol=100:1->30:1), so as to obtain 7-((R)-5-hydroxymethyl-2-oxooxazolidin-3-yl)-3-(2-methanesulfonylphenyl)-2H-isoquinolin-1-one (2 mg, 26%) in the form of a colorless oil substance.

1. temperatureunder heating
2. temperatureto reflux overnight
3. extractionthe mixture was extracted with ethyl acetate
4. dry with materialThe extract was dried over anhydrous sodium sulfate
5. distillationthe solvent was distilled away under reduced pressure
6. customThe obtained residue was purified by silica gel column chromatography (methylene chloride:methanol=100:1->30:1)