4-Hydroxymethyl-pyrrolidin-2-one → 7-(4-Hydroxymethyl-2-oxopyrrolidin-1-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one

HRID 1162923Notes

Reaction equation

HRID 1162923 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:7][NH:6][C:5](=[O:8])[CH2:4]1.I[C:10]1[CH:19]=[C:18]2[C:13]([CH:14]=[C:15]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]([F:30])([F:29])[F:28])[NH:16][C:17]2=[O:20])=[CH:12][CH:11]=1>>[OH:1][CH2:2][CH:3]1[CH2:7][N:6]([C:10]2[CH:19]=[C:18]3[C:13]([CH:14]=[C:15]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[C:27]([F:29])([F:28])[F:30])[NH:16][C:17]3=[O:20])=[CH:12][CH:11]=2)[C:5](=[O:8])[CH2:4]1

Participants

3

Reactant 2

HCID 152563274-Hydroxymethyl-pyrrolidin-2-oneHCID 231568037-iodo-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one

Product 1

HCID 118570997-(4-Hydroxymethyl-2-oxopyrrolidin-1-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one

Procedure

4-Hydroxymethylpyrrolidin-2-one, which is a known compound described in a publication (Journal of Chemical Research, Synopses, vol. 9, pp. 430-431, (1996)) and the 7-iodo-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one obtained in step D of Example 1-1 were used as raw materials. Using such raw materials, the captioned compound was synthesized by a reaction similar to step E of Example 1-1.

Workup

  1. customthe captioned compound was synthesized by a reaction similar to step E of Example 1-1

Sources & evidence

ORD record
ord-ab8eda228d6a47ee81fc72771186a7f7
Source dataset
uspto-grants-2010_10
Patent number
US07820693B2

Reaction notes

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