HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxymethyl-pyrrolidin-2-one → 7-(4-Hydroxymethyl-2-oxopyrrolidin-1-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxymethyl-pyrrolidin-2-one | HCID 15256327 | — |
| Reactant | 7-iodo-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one | HCID 23156803 | — |
| Product | 7-(4-Hydroxymethyl-2-oxopyrrolidin-1-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one | HCID 11857099 | — |
Reaction Steps
4-Hydroxymethylpyrrolidin-2-one, which is a known compound described in a publication (Journal of Chemical Research, Synopses, vol. 9, pp. 430-431, (1996)) and the 7-iodo-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one obtained in step D of Example 1-1 were used as raw materials. Using such raw materials, the captioned compound was synthesized by a reaction similar to step E of Example 1-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820693B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-ab8eda228d6a47ee81fc72771186a7f7 |
| Source note | uspto-grants-2010_10 |