反应详情

温度

180 °C

A mixture of 28.6 g (100 mmol) of 1-(2-bromophenyl)-3,4-dihydroisoquinoline, 86.9 g (1 mol) of manganese dioxide and 200 ml of 1,2-dichlorobenzene was stirred at 180° C. for 5 h. After cooling, the mixture was diluted with 500 ml of toluene and filtered through silica gel. After the solvent had been removed, the product was obtained as a yellow oil. The yield at a purity of approx. 99.0% was 26.0 g (91 mmol), 91.4% of theory.

1. temperatureAfter cooling
2. filtrationfiltered through silica gel
3. customAfter the solvent had been removed
4. customthe product was obtained as a yellow oil
5. customThe yield at a purity of approx. 99.0%