関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1,2-Dichlorobenzene | HCID 7239 | — |
| 反応物 | 1-(2-Bromophenyl)-3,4-dihydroisoquinoline | HCID 10779537 | — |
| 触媒 | HCID 178418406 | HCID 178418406 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-(2-Bromophenyl)isoquinoline | HCID 11403358 | — |
反応手順
A mixture of 28.6 g (100 mmol) of 1-(2-bromophenyl)-3,4-dihydroisoquinoline, 86.9 g (1 mol) of manganese dioxide and 200 ml of 1,2-dichlorobenzene was stirred at 180° C. for 5 h. After cooling, the mixture was diluted with 500 ml of toluene and filtered through silica gel. After the solvent had been removed, the product was obtained as a yellow oil. The yield at a purity of approx. 99.0% was 26.0 g (91 mmol), 91.4% of theory.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07820822B2 |
|---|
| 出典データセット | uspto-grants-2010_10 |
|---|
| ORD ID | ord-9938ca1c516e454e9e3d85c01e6cd1a8 |
|---|
| 出典メモ | uspto-grants-2010_10 |
|---|
