反应详情

4-Cyclopentylamino-6-hydroxy-quinazoline-2-carbonitrile (0.4 mmol), 1-(2-Chloro-ethyl)-4-methyl-piperazine dihydrochloride (0.55 mmol) and cesium carbonate (4 mmol) are stirred in DMF (5 ml) at RT for 20 hours. The suspension is filtered, washed with little DMF and water is added to the filtrate until the solution gets turbide. The precipitate formed is filtered off, washed with water and dried (vacuum). A powder with mp. 110-112° C., Rf=0.48 (CH2Cl2/MeOH=9:2) is obtained.

1. filtrationThe suspension is filtered
2. washwashed with little DMF and water
3. additionis added to the filtrate until the solution
4. customThe precipitate formed
5. filtrationis filtered off
6. washwashed with water
7. customdried (vacuum)
8. customA powder with mp. 110-112° C., Rf=0.48 (CH2Cl2/MeOH=9:2) is obtained