huagongshe.com
HRID1163004

反应详情

EQUATION

反应方程式

HRID 1163004 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

2 次

结构：O=C([O-])[O-].[Cs+].[Cs+]
HCID10796

Cesium carbonate

CCs2O3

结构：Cl.ClCc1ccncc1
HCID74570

4-(Chloromethyl)pyridinium chloride

C6H7Cl2N

结构：CC(C)(C)CNc1nc(C#N)nc2ccc(O)cc12
HCID68647238

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)CNc1nc(C#N)nc2ccc(OCc3ccncc3)cc12
HCID68647392

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

4-(2,2-Dimethyl-propylamino)-6-hydroxy-quinazoline-2-carbonitrile (0.23 mmol), 4-chloromethyl-pyridine hydrochloride (0.35 mmol) and cesium carbonate (2.3 mmol) are stirred in DMF (3 ml) at RT for 20 hours. Water is added until a clear solution is formed. Then more water is added until the solution gets turbide. The precipitate formed is filtered off, washed with water and dried (vacuum). A powder with mp. 203-205° C., Rf=0.2 (CH2Cl2/MeOH=15:1) is obtained.

WORKUP

后处理

  1. customis formed
  2. customThe precipitate formed
  3. filtrationis filtered off
  4. washwashed with water
  5. customdried (vacuum)
  6. customA powder with mp. 203-205° C., Rf=0.2 (CH2Cl2/MeOH=15:1) is obtained