反应详情

4-(2,2-Dimethyl-propylamino)-6-hydroxy-quinazoline-2-carbonitrile (0.25 mmol), 3-chloromethyl-pyridine hydrochloride (0.38 mmol) and cesium carbonate (2.5 mmol) are stirred in DMF (3 ml) at RT for 20 hours. Water is added until a clear solution is formed. Then more water is added until the solution gets turbide. The precipitate formed is filtered off, washed with water and dried (vacuum). A powder with mp. 156-158° C., Rf=0.35 (CH2Cl2/MeOH=15:1) is obtained.

1. customis formed
2. customThe precipitate formed
3. filtrationis filtered off
4. washwashed with water
5. customdried (vacuum)
6. customA powder with mp. 156-158° C., Rf=0.35 (CH2Cl2/MeOH=15:1) is obtained