1-(3-(Benzyloxy)-2-fluoro-6-nitrophenyl)propan-2-one → 4-fluoro-2-methyl-1H-indol-5-ol

HRID 1163049Notes

Reaction equation

HRID 1163049 reaction equation
C([O:8][C:9]1[C:10]([F:22])=[C:11]([CH2:18][C:19](=O)[CH3:20])[C:12]([N+:15]([O-])=O)=[CH:13][CH:14]=1)C1C=CC=CC=1.FC1C(O)=CC=C([N+]([O-])=O)C=1CC(=O)C>>[F:22][C:10]1[C:9]([OH:8])=[CH:14][CH:13]=[C:12]2[C:11]=1[CH:18]=[C:19]([CH3:20])[NH:15]2

Participants

3

Reactant 2

HCID 112896631-(3-(Benzyloxy)-2-fluoro-6-nitrophenyl)propan-2-oneHCID 223379951-(2-Fluoro-3-hydroxy-6-nitrophenyl)propan-2-one

Product 1

HCID 103520364-fluoro-2-methyl-1H-indol-5-ol

Procedure

1-(3-Benzyloxy-2-fluoro-6-nitro-phenyl)-propan-2-one can also be converted to 1-(2-fluoro-3-hydroxy-6-nitrophenyl)-propan-2-one by the following two alternate methods.

Sources & evidence

ORD record
ord-ed16158532954d76acd9a1d1cf945bb5
Source dataset
uspto-grants-2010_10
Patent number
US07820814B2

Reaction notes

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