反应详情

To a solution of ethyl {5-[(2′,6′-dimethylbiphenyl-3-yl)methoxy]-1H-indol-1-yl}acetate (0.27 g, 0.65 mmol) in a mixed solvent of methanol (10 mL) and tetrahydrofuran (10 mL) was added 85% aqueous solution (5 mL) of potassium hydroxide (0.13 g, 1.97 mmol), and the mixture was stirred at room temperature for 18 hr. Water was added to the reaction mixture, and the mixture was made weak acidic with 10% aqueous citric acid solution and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:2-2:1) to give the title compound (0.19 g, yield 76%) as a pale-yellow amorphous solid.

1. extractionextracted with ethyl acetate
2. washThe extract was washed with saturated brine
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationconcentrated under reduced pressure
5. customThe residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:2-2:1)