反应详情

温度

120 °C

A mixture of diethyl {2-[(3-phenoxybenzyl)thio]-4,5,6,7-tetrahydro-1,3-benzothiazol-7-yl}malonate (1.21 g, 2.36 mmol), 37% hydrochloric acid (10 mL) and acetic acid (10 mL) was heated with stirring at 120° C. for 12 hr. The reaction mixture was concentrated, and the residue was diluted with ethyl acetate, washed successively with 10% aqueous sodium hydrogen carbonate solution and saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the title compound (890 mg, 92%) as a pale-yellow oil.

1. temperaturewas heated
2. concentrationThe reaction mixture was concentrated
3. additionthe residue was diluted with ethyl acetate
4. washwashed successively with 10% aqueous sodium hydrogen carbonate solution and saturated brine
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated under reduced pressure