HCID 11166034, compound → HCID 11255641, compound

HRID 1163352Notes

Reaction equation

HRID 1163352 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:24][C@H:23]([CH2:25][NH:26][C:27](=[O:29])[CH3:28])[O:22][C:21]3=[O:30])=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.CO>[O:30]=[C:21]1[N:20]([C:17]2[CH:16]=[N:15][C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[CH:19][CH:18]=2)[CH2:24][C@H:23]([CH2:25][NH:26][C:27](=[O:29])[CH3:28])[O:22]1

Participants

4

Reactant 1

HCID 11166034HCID 11166034, compound

Product 1

HCID 11255641HCID 11255641, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

0.54 g of 4-{5-[(5S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-pyridin-2-yl}-piperazine-1-carboxylic acid tert-butyl ester (1.28 mmol) was dissolved in a 1.25 M HCl solution in methanol. The solution was stirred and the reaction monitored by TLC. The methanol was evaporated, the residue dissolved in water, neutralized with sodium bicarbonate and the water evaporated to dryness. The residue was digested in a 9/1 dichloromethane/methanol. The insoluble salt was filtered off, the filtrate evaporated to dryness to leave a pale brown solid.

Workup

  1. customThe methanol was evaporated
  2. dissolutionthe residue dissolved in water
  3. customthe water evaporated to dryness
  4. filtrationThe insoluble salt was filtered off
  5. customthe filtrate evaporated to dryness
  6. customto leave a pale brown solid

Sources & evidence

ORD record
ord-c069dab713624c538009cdd896c10e88
Source dataset
uspto-grants-2010_10
Patent number
US07820823B2

Reaction notes

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