Chlorotrimethylsilane → HCID 58916239, compound

HRID 1163359Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([N:15]2[CH2:19][C@H:18]([CH2:20][NH:21][C:22](=[O:24])[CH3:23])[O:17][C:16]2=[O:25])[CH:5]=[CH:6][C:7]=1[NH:8][CH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.Cl[C:27]1[N:36]=[C:35]2[C:30]([C:31](=[O:43])[C:32]([C:40]([OH:42])=[O:41])=[CH:33][N:34]2[CH:37]2[CH2:39][CH2:38]2)=[CH:29][C:28]=1[F:44].C[Si](C)(C)Cl.C(N(CC)CC)C>CS(C)=O>[C:22]([NH:21][CH2:20][C@@H:18]1[O:17][C:16](=[O:25])[N:15]([C:4]2[CH:5]=[CH:6][C:7]([NH:8][CH:9]3[CH2:14][CH2:13][N:12]([C:27]4[N:36]=[C:35]5[C:30]([C:31](=[O:43])[C:32]([C:40]([OH:42])=[O:41])=[CH:33][N:34]5[CH:37]5[CH2:39][CH2:38]5)=[CH:29][C:28]=4[F:44])[CH2:11][CH2:10]3)=[C:2]([F:1])[CH:3]=2)[CH2:19]1)(=[O:24])[CH3:23]

Participants

Conditions

Temperature: 150 °C

Procedure

A suspension of 100 mg N-{(5S)-3-[3-fluoro-4-(piperidin 4-ylamino)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}acetamide (0.28 mmol), 80.66 mg 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (0.28 mmol), 0.108 ml trimethylchlorosilane (0.84 mmol) and 0.16 ml triethylamine (1.12 mmol) in 2 ml DMSO was heated under stirring in a micro wave oven at 150° C. for 7 min: The DMSO was evaporated, the residue was purified by chromatography.

Workup

temperaturewas heated
customThe DMSO was evaporated
customthe residue was purified by chromatography

Sources & evidence

ORD record: ord-1a7567a72fd54e11a340eda3d25c5d16
Source dataset: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07820823B2

Reaction notes

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