反应详情

To a solution of 2-chloro-5-nitro-1H-benzimidazole (1.5 mmol; prepared from nitration of 2-chloro-1H-benzimidazole; Galy et al., J. Heterocycl. Chem. 1997, 34, 6, 1781-1788) in dry NMP (3 mL) was added 2-isopropylaniline (4 mmol). The resulting solution was subjected to microwave irradiation at 150° C. for 1 h. The contents were cooled to room temperature, diluted with water (20 mL) and extracted with EtOAc (2×15 mL). The combined extracts were then washed with water (20 mL) and brine (20 mL) and dried over anhydrous sodium sulfate. The solvent was removed in vacuo and the residue obtained was purified by silica gel chromatography using EtOAc/hexane as eluent to obtain (2-isopropylphenyl)-(5-nitro-1H-benzimidazol-2-yl)-amine as light yellow solid.

1. customirradiation at 150° C. for 1 h
2. extractionextracted with EtOAc (2×15 mL)
3. washThe combined extracts were then washed with water (20 mL) and brine (20 mL)
4. dry with materialdried over anhydrous sodium sulfate
5. customThe solvent was removed in vacuo
6. customthe residue obtained
7. customwas purified by silica gel chromatography