Hydrochloric Acid → HCID 178426311, compound

HRID 1163410Notes

Reaction equation

HRID 1163410 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:30]([C:31](=[O:42])[NH:32][C:33]3[CH:41]=[CH:40][C:36]4[N:37]=[CH:38][S:39][C:35]=4[CH:34]=3)=[CH:29][C:17]3[N:18]=[C:19]([NH:21][C:22]4[C:27]([CH3:28])=[CH:26][CH:25]=[CH:24][N:23]=4)[NH:20][C:16]=3[CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[S:39]1[C:35]2[CH:34]=[C:33]([NH:32][C:31]([C:30]3[C:14]([N:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)=[CH:15][C:16]4[NH:20][C:19]([NH:21][C:22]5[C:27]([CH3:28])=[CH:26][CH:25]=[CH:24][N:23]=5)=[N:18][C:17]=4[CH:29]=3)=[O:42])[CH:41]=[CH:40][C:36]=2[N:37]=[CH:38]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178426312HCID 178426312, compound

Product 1

HCID 178426311HCID 178426311, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product from Example 165 was treated with 4M HCl in dioxane employing the procedure described for Example 156 to afford 2-(3-Methyl-pyridin-2-ylamino)-6-piperazin-1-yl-1H-benzoimidazole-5-carboxylic acid benzothiazol-6-ylamide as a hydrochloride salt. MS: m/z 485 (M+H)+.

Sources & evidence

ORD record
ord-190755dc50914018bd6bb064cc4c6744
Source dataset
uspto-grants-2010_10
Patent number
US07820821B2

Reaction notes

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