Piperazine → HCID 68443489, compound

HRID 1163415Notes

Reaction equation

[NH2:1][C:2]1[C:19]([N+:20]([O-:22])=[O:21])=[CH:18][C:5]([C:6]([NH:8][C:9]2[CH:17]=[C:16]3[C:12]([CH:13]=[N:14][NH:15]3)=[CH:11][CH:10]=2)=[O:7])=[C:4](Cl)[CH:3]=1.[NH:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>>[NH2:1][C:2]1[C:19]([N+:20]([O-:22])=[O:21])=[CH:18][C:5]([C:6]([NH:8][C:9]2[CH:17]=[C:16]3[C:12]([CH:13]=[N:14][NH:15]3)=[CH:11][CH:10]=2)=[O:7])=[C:4]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:3]=1

Participants

Reactant 2

HCID 4837Piperazine

HCID 68443943HCID 68443943, compound

Product 1

HCID 68443489HCID 68443489, compound

Procedure

A solution 4-amino-2-chloro-N-(1H-indazol-6-yl)-5-nitrobenzamide (1 mmol; see Example 154) was reacted with piperazine following the procedure described in Example 163 to afford 4-amino-N-(1H-indazol-6-yl)-5-nitro-2-piperazin-1-ylbenzamide. The product thus obtained was treated with BOC anhydride as in Example 163 to obtain 4-[5-amino-2-(1H-indazol-6-ylcarbamoyl)-4-nitro-phenyl]-piperazine-1-carboxylic acid tert-butyl ester.

Sources & evidence

ORD record: ord-e780839a96894145b29eb316189c7522
Source dataset: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07820821B2

Reaction notes

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