HCID 178506142, compound → HCID 178506143, compound

HRID 1163441Notes

Reaction equation

HRID 1163441 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]#[C:11][C:12]3[CH:31]=[CH:30][C:15]4[NH:16][C:17]([NH:19][C:20]5[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=5[C:26]([F:29])([F:28])[F:27])=[N:18][C:14]=4[CH:13]=3)[CH:8]=2)[CH:3]=[N:2]1>C(O)C>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH2:10][CH2:11][C:12]3[CH:31]=[CH:30][C:15]4[NH:16][C:17]([NH:19][C:20]5[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=5[C:26]([F:29])([F:27])[F:28])=[N:18][C:14]=4[CH:13]=3)[CH:8]=2)[CH:3]=[N:2]1

Participants

3

Reactant 1

HCID 178506142HCID 178506142, compound

Product 1

HCID 178506143HCID 178506143, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of [5-(1H-Indazol-6-ylethynyl)-1H-benzoimidazol-2-yl]-(2-trifluoromethylphenyl)-amine (0.3 mmol; see Example 159) in ethanol (3 mL) was reduced under hydrogenation conditions at 50 psi as described in general procedure to yield {5-[2-(1H-indazol-6-yl)-ethyl]-1H-benzimidazol-2-yl}-(2-trifluoromethylphenyl)amine. MS: m/z 422 (M+H)+.

Sources & evidence

ORD record
ord-617548b1056e4cb283e131159bd120a8
Source dataset
uspto-grants-2010_10
Patent number
US07820821B2

Reaction notes

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