Hydrochloric Acid → 2-(4,6-Dimethoxypyrimidine-2-ylcarbonyl)aniline

HRID 1163452ノート

反応式

HRID 1163452 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([C:11]([CH2:13][C:14]([NH:16]C2C=CC=CC=2)=O)=[O:12])[N:4]=1.Cl.[OH-].[Na+]>CO>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([C:11]([C:13]2[CH:14]=[CH:13][CH:11]=[CH:5][C:14]=2[NH2:16])=[O:12])[N:6]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178567622-(4,6-Dimethoxypyrimidine-2-ylcarbonyl)acetanilide

生成物 1

HCID 178567502-(4,6-Dimethoxypyrimidine-2-ylcarbonyl)aniline

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

In a reactor were placed 0.57 g (1.9 m moles) of 2-(4,6-dimethoxypyrimidine-2-ylcarbonyl)acetanilide, 10 ml of methanol and 5 ml of 6 N hydrochloric acid, followed by refluxing for 1 hour with heating. After the completion of the reaction, the reaction mixture was made alkaline with sodium hydroxide, after which extraction with ethyl acetate was made. The ethyl acetate layer was concentrated. The residue was subjected to gas chromatography. As a result, formation of 2-(4,6-dimethoxypyrimidine-2-ylcarbonyl)aniline was confirmed. Conversion: 1000 (in terms of total area ratio in gas chromatography)

後処理

  1. customIn a reactor were placed
  2. temperatureby refluxing for 1 hour
  3. temperaturewith heating
  4. customAfter the completion of the reaction
  5. extractionafter which extraction with ethyl acetate
  6. concentrationThe ethyl acetate layer was concentrated

出典と根拠

ORDレコード
ord-82890aff169c41dabb7f536d4dff751e
出典データセット
uspto-grants-2010_10
特許番号
US07820861B2

反応ノート

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