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In a reactor were placed 0.57 g (1.9 m moles) of 2-(4,6-dimethoxypyrimidine-2-ylcarbonyl)acetanilide, 10 ml of methanol and 5 ml of 6 N hydrochloric acid, followed by refluxing for 1 hour with heating. After the completion of the reaction, the reaction mixture was made alkaline with sodium hydroxide, after which extraction with ethyl acetate was made. The ethyl acetate layer was concentrated. The residue was subjected to gas chromatography. As a result, formation of 2-(4,6-dimethoxypyrimidine-2-ylcarbonyl)aniline was confirmed. Conversion: 1000 (in terms of total area ratio in gas chromatography)

1. customIn a reactor were placed
2. temperatureby refluxing for 1 hour
3. temperaturewith heating
4. customAfter the completion of the reaction
5. extractionafter which extraction with ethyl acetate
6. concentrationThe ethyl acetate layer was concentrated