Ethanol → HCID 20438511, compound

HRID 1163864Notes

Reaction equation

HRID 1163864 reaction equation
[NH2:1][C:2]1[NH:3][CH2:4][CH2:5][CH:6]=1.C([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][C:16]([O:18]CC)=O)=O.[CH2:21](O)C>>[C:10]1([C:15]2[C:16](=[O:18])[N:1]=[C:2]3[CH2:6][CH2:5][CH2:4][N:3]3[CH:21]=2)[CH:9]=[CH:14][CH:13]=[CH:12][CH:11]=1.[C:10]1([C:15]2[C:16](=[O:18])[N:3]3[CH2:4][CH2:5][CH2:6][C:2]3=[N:1][CH:21]=2)[CH:9]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 12241428HCID 12241428, compoundHCID 18368243HCID 18368243, compound

Product 2

HCID 20438511HCID 20438511, compoundHCID 20438533HCID 20438533, compound

Procedure

8.4 g. of 2-amino-pyrroline and 19.2 g. of ethyl 2-formyl-phenyl-acetate are heated in 150 ml. ethanol for 5 hours and the reaction mixture is evaporated. The residue is treated with petrol ether, the obtained crystals are filtered. 15.9 g. (75%) of a mixture of 3-phenyl-2-oxo-2,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine and 3-phenyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine are obtained, melting slowly between 98° to 120° C.

Workup

  1. customthe reaction mixture is evaporated
  2. additionThe residue is treated with petrol ether
  3. filtrationthe obtained crystals are filtered

Sources & evidence

ORD record
ord-bd96f6b55d4f4773a8ed2e4efa3a6bcc
Source dataset
uspto-grants-1983_01
Patent number
US04367229

Reaction notes

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