Ammonium Hydroxide → HCID 20438499, compound

HRID 1163865Notes

Reaction equation

HRID 1163865 reaction equation
[O:1]=[C:2]1[N:7]2[CH2:8][CH2:9][CH2:10][C:6]2=[N:5][CH:4]=[C:3]1[C:11]([O:13]CC)=O.[OH-].[NH4+:17]>>[C:11]([C:3]1[C:2](=[O:1])[N:7]2[CH2:8][CH2:9][CH2:10][C:6]2=[N:5][CH:4]=1)(=[O:13])[NH2:17]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 12778914HCID 12778914, compound

Product 1

HCID 20438499HCID 20438499, compoundYield 96.6%

Procedure

10.4 g. of ethyl 4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-3-carboxylate are dissolved in 30 ml. of 30% by weight of ammonium hydroxide solution. The precipitated crystals are filtered after 2 hours. 8.7 g. of 3-carbamoyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine are obtained with a yield of 96.6%, which melts at 293° C. after recrystallization from dimethyl formamide.

Workup

  1. filtrationThe precipitated crystals are filtered after 2 hours

Sources & evidence

ORD record
ord-91c51cfeca9746009bf269c16f73e9a9
Source dataset
uspto-grants-1983_01
Patent number
US04367229

Reaction notes

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