Dimethyl Sulfate → HCID 20438521, compound

HRID 1163869Notes

Reaction equation

HRID 1163869 reaction equation
[C:1]([C:4]1[C:9](=[O:10])[N:8]2[CH2:11][CH2:12][CH2:13][C:7]2=[N:6][CH:5]=1)(=[O:3])[NH2:2].[S:14]([O:19]C)([O:17][CH3:18])(=[O:16])=[O:15]>C(O)CCC>[CH3:18][O:17][S:14]([O-:19])(=[O:16])=[O:15].[C:1]([C:4]1[C:9](=[O:10])[N:8]2[CH2:11][CH2:12][CH2:13][C:7]2=[N+:6]([CH3:18])[CH:5]=1)(=[O:3])[NH2:2]

Participants

4

Reactant 2

HCID 6497Dimethyl SulfateHCID 20438499HCID 20438499, compound

Product 1

HCID 20438521HCID 20438521, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Conditions

Temperature
100 °C

Procedure

To a solution of 5.37 g. of 3-carbamoyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine in 540 ml. of n-butanol 3.78 g. of dimethyl sulphate are added and the reaction mixture is stirred for 3 hours at 100° C. whereafter the solvent is distilled off. The residue is triturated with acetone and the obtained crystals are filtered. 3.7 g. (51%) highly hygroscopic 3-carbamoyl-1-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidinium methyl sulphate are obtained melting at 190° C. under decomposition.

Workup

  1. distillationis distilled off
  2. customThe residue is triturated with acetone
  3. filtrationthe obtained crystals are filtered

Sources & evidence

ORD record
ord-2b03fa5f2c0d41feac19723728223ea8
Source dataset
uspto-grants-1983_01
Patent number
US04367229

Reaction notes

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