Dimethyl Sulfate → HCID 20438521, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5.37 g. of 3-carbamoyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine in 540 ml. of n-butanol 3.78 g. of dimethyl sulphate are added and the reaction mixture is stirred for 3 hours at 100° C. whereafter the solvent is distilled off. The residue is triturated with acetone and the obtained crystals are filtered. 3.7 g. (51%) highly hygroscopic 3-carbamoyl-1-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidinium methyl sulphate are obtained melting at 190° C. under decomposition.

Provenance & Evidence