反应详情

A methylene chloride solution of 4.05 g (0.02 m) 5-chloro-2-mercaptothiazolo[5,4-b]pyridine, 4.30 g (0.02 m) α-bromophenylacetic acid and 4.0 g (0.04 m) triethylamine is heated to gentle reflux overnight. The methylene chloride solution is extracted twice with a dilute hydrochloric acid solution and once with water and then dried over anhydrous MgSO4. After the solvent is removed, the residual solid is recrystallized from acetonitrile. 5.0 g (74% yield) of title compound, melting at 175°-7° C., is obtained.

1. temperatureto gentle reflux overnight
2. extractionThe methylene chloride solution is extracted twice with a dilute hydrochloric acid solution and once with water
3. dry with materialdried over anhydrous MgSO4
4. customAfter the solvent is removed
5. customthe residual solid is recrystallized from acetonitrile