Hydrochloric Acid → HCID 20513292, compound

HRID 1163932Notes

Reaction equation

HRID 1163932 reaction equation
F[C:2]1C(OC)=C(C(O[Si](C)(C)C)C#N)C=C(C)C=1.[ClH:19].Cl.[F:21][C:22]1[C:23](OC)=[C:24]([CH:29]([OH:35])[C:30](=[NH:34])[O:31][CH2:32][CH3:33])[CH:25]=[C:26](C)[CH:27]=1>>[ClH:19].[F:21][C:22]1[C:23]([CH3:2])=[C:24]([CH:29]([OH:35])[C:30](=[NH:34])[O:31][CH2:32][CH3:33])[CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 13216662HCID 13216662, compoundHCID 20459880HCID 20459880, compound

Product 1

HCID 20513292HCID 20513292, compound

Procedure

By the procedure of Example 65, 2-(3-fluoro-2-methoxy-5-methylphenyl)-2-trimethylsiloxyethanenitrile (0.48 g., 1.79 mmoles) in 20 ml. of saturated ethanolic hydrogen chloride was converted to ethyl 1-(3-fluoro-2-methoxy-5-methylphenyl)-1-hydroxymethanecarboximidate hydrochloride [0.36 g.; m.p. 105°-106° C. (dec)].

Sources & evidence

ORD record
ord-86fb1a7f91ff48aea01f7dafbbf5f3a3
Source dataset
uspto-grants-1983_01
Patent number
US04367234

Reaction notes

Loading…