Tetrahydrofuran → HCID 13092023, compound

HRID 1163933Notes

Reaction equation

HRID 1163933 reaction equation
Cl.[CH2:2]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:6]=1[CH:12]([OH:18])[C:13](=[NH:17])[O:14]CC)[CH3:3].[O:19]1CCC[CH2:20]1>>[CH2:2]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:6]=1[CH:12]1[O:18][C:20](=[O:19])[NH:14][C:13]1=[O:17])[CH3:3]

Participants

3

Reactant 2

HCID 8028TetrahydrofuranHCID 13599069HCID 13599069, compound

Product 1

HCID 13092023HCID 13092023, compound

Procedure

By the procedure of Example 66, using a reaction time of 3 hours at room temperature, ethyl 1-(2-ethoxy-6-fluorophenyl)-1-hydroxymethanecarboximidate hydrochloride (0.56 g., 2 mmoles) in 55 ml. of tetrahydrofuran was converted to crude product. Recrystallization from toluene afforded purified 5-(2-ethoxy-6-fluorophenyl)oxazolidine-2,4-dione. (147 mg., m.p. 127°-128° C.).

Workup

  1. customa reaction time of 3 hours
  2. customat room temperature
  3. customRecrystallization from toluene
  4. customafforded
  5. custompurified 5-(2-ethoxy-6-fluorophenyl)oxazolidine-2,4-dione

Sources & evidence

ORD record
ord-12994d170de24d36a792b648b0adddfd
Source dataset
uspto-grants-1983_01
Patent number
US04367234

Reaction notes

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