Tetrahydrofuran → HCID 13092036, compound

HRID 1163947Notes

Reaction equation

HRID 1163947 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:15][CH3:16])=[C:6]([CH:8]2[O:12][C:11](=[O:13])[NH:10][C:9]2=[O:14])[CH:7]=1.[O:17]1CC[CH2:19][CH2:18]1>C(OC(=O)C)(=O)C>[C:18]([N:10]1[C:9](=[O:14])[CH:8]([C:6]2[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=2[O:15][CH3:16])[O:12][C:11]1=[O:13])(=[O:17])[CH3:19]

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 13092002HCID 13092002, compound

Product 1

HCID 13092036HCID 13092036, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideCatalyst

Procedure

5-(5-chloro-2-methoxyphenyl)oxazolidine-2,4-dione (100 mg.) was dissolved in 2.5 ml. of tetrahydrofuran. Excess acetic anhydride (4 drops) was added, and the mixture allowed to stand at room temperature for 16 hours. Evaporation to dryness gave 3-acetyl-5-(5-chloro-2-methoxyphenyl)oxazolidine-2,4-dione [Rf 0.75 (1:1 ethyl acetate:chloroform; m.p. 160°-162° C⟧

Workup

  1. customEvaporation to dryness

Sources & evidence

ORD record
ord-6171879c35354e0ba0fbfb3c296f9734
Source dataset
uspto-grants-1983_01
Patent number
US04367234

Reaction notes

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