Acetic Acid → 2-[2-Methoxy-3-(3-chlorophenoxy)phenyl]acetic acid

HRID 1164013Notes

Reaction equation

HRID 1164013 reaction equation
[CH3:1][O:2][C:3]1[C:8]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[CH:11]=2)=[CH:7][CH:6]=[CH:5][C:4]=1CC#N.Cl.[C:21]([OH:24])(=[O:23])[CH3:22]>>[CH3:1][O:2][C:3]1[C:8]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[CH:11]=2)=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:22][C:21]([OH:24])=[O:23]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 205134902-[2-Methoxy-3-(3-chlorophenoxy)phenyl]acetonitrile

Product 1

HCID 205134882-[2-Methoxy-3-(3-chlorophenoxy)phenyl]acetic acid

Procedure

2-[2-Methoxy-3-(3-chlorophenoxy)phenyl]acetonitrile (16.4 g), glacial acetic acid (80 ml) and conc. hydrochloric acid (30 ml) were treated in a similar manner to that of Example 5-(4) to give oily 2-[2-methoxy-3-(3-chlorophenoxy)phenyl]acetic acid (10.1 g).

Sources & evidence

ORD record
ord-445912a6893b421daa7cd029e403f9b8
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

Loading…