Hydrochloric Acid → HCID 20513427, compound

HRID 1164032Notes

Reaction equation

HRID 1164032 reaction equation
[C:1]([C:3]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH3:23])[C:11]=1[O:24][CH3:25])(C)[C:4]([O:6]CC)=[O:5])#N.Cl>C(O)(=O)C>[CH3:25][O:24][C:11]1[C:12]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH3:23])=[CH:13][CH:14]=[CH:15][C:10]=1[CH:3]([CH3:1])[C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20513435HCID 20513435, compound

Product 1

HCID 20513427HCID 20513427, compoundYield 56.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of ethyl 2-cyano-2-[2-methoxy-3-(o-tolyloxy)phenyl]propionate (6.1 g), conc. hydrochloric acid (20 ml) and acetic acid (40 ml) was refluxed under heating for 48 hours. The reaction mixture was treated in a similar manner to that of Example 10-(6) to give oily 2-[2-methoxy-3-(o-tolyloxy)phenyl]propionic acid (2.9 g).

Workup

  1. temperaturewas refluxed
  2. temperatureunder heating for 48 hours
  3. additionThe reaction mixture was treated in a similar manner to that of Example 10-(6)

Sources & evidence

ORD record
ord-b87d32b956934f9d96beaceff06c3cfa
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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