Hydrogen iodide → HCID 13066706, compound

HRID 1164038Notes

Reaction equation

HRID 1164038 reaction equation
I.CO[C:4]1[C:9]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])=[CH:8][CH:7]=[CH:6][C:5]=1[CH:18]([CH2:22][CH3:23])[C:19]([OH:21])=[O:20].OC1C(OC2C=CC=CC=2C)=CC=CC=1C(CC)C(O)=O>C(OC(=O)C)(=O)C>[CH2:22]([CH:18]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([O:10][C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[CH3:17])[C:4]=2[O:20][C:19]1=[O:21])[CH3:23]

Participants

5

Reactant 3

HCID 24841Hydrogen iodideHCID 20513478HCID 20513478, compoundHCID 20513510HCID 20513510, compound

Product 1

HCID 13066706HCID 13066706, compoundYield 33.1%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent2×

Procedure

Hydriodic acid (55-58%, 20 ml) and a solution of 2-[2-methoxy-3-(o-tolyloxy)phenyl]butyric acid (2.2 g) in acetic anhydride (10 ml) were treated in a similar manner to that of Example 10-(7). The resultant product, i.e. 2-[2-hydroxy-3-(o-tolyloxy)phenyl]butyric acid was treated with acetic anhydride (20 ml) in a similar manner to that of Example 10-(7) to give 3-ethyl-7-(o-tolyloxy)-2,3-dihydrobenzofuran-2-one (650 mg). mp 44°-45° C.

Sources & evidence

ORD record
ord-adec77e8800b42f1ba567b0a2ef73dcb
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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