Methyl iodide → HCID 20513466, compound

HRID 1164044Notes

Reaction equation

HRID 1164044 reaction equation
[H-].[Na+].[C:3]([CH:5]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[F:24])[C:12]=1[O:25][CH3:26])[C:6]([O:8][CH2:9][CH3:10])=[O:7])#[N:4].[CH3:27]I>>[C:3]([C:5]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[F:24])[C:12]=1[O:25][CH3:26])([CH3:27])[C:6]([O:8][CH2:9][CH3:10])=[O:7])#[N:4]

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 20513410HCID 20513410, compound

Product 1

HCID 20513466HCID 20513466, compoundYield 85%

Procedure

Sodium hydride (50%, 1 g), ethyl 2-cyano-2-[2-methoxy-3-(2-fluorophenoxy)phenyl]acetate (7 g) and methyl iodide (4.14 g) were treated in a similar manner to that of Example 10-(5) to give oily ethyl 2-cyano-2-[2-methoxy-3-(2-fluorophenoxy)phenyl]propionate (6.2 g).

Sources & evidence

ORD record
ord-41481084d26c4dfc87641ccafa8c3a31
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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