Potassium Hydroxide → 2-[2-Methoxy-3-(2-chlorophenoxy)phenyl]butyric acid

HRID 1164048Notes

Reaction equation

HRID 1164048 reaction equation
C([C:3]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[Cl:24])[C:12]=1[O:25][CH3:26])([CH2:9][CH3:10])[C:4]([O:6]CC)=[O:5])#N.[OH-].[K+]>C(O)C.O>[CH3:26][O:25][C:12]1[C:13]([O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[Cl:24])=[CH:14][CH:15]=[CH:16][C:11]=1[CH:3]([CH2:9][CH3:10])[C:4]([OH:6])=[O:5]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 20513442Ethyl 2-cyano-2-[2-methoxy-3-(2-chlorophenoxy)phenyl]butyrate

Product 1

HCID 205134672-[2-Methoxy-3-(2-chlorophenoxy)phenyl]butyric acidYield 82%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of ethyl 2-cyano-2-[2-methoxy-3-(2-chlorophenoxy)phenyl]butyrate (5.9 g) and potassium hydroxide (4.5 g) in ethanol (80 ml) and water (40 ml) was treated in a similar manner to that of Example 14-(7). The resultant residue was washed with n-hexane and dried to give 2-[2-methoxy-3-(2-chlorophenoxy)phenyl]butyric acid (4.15 g).

Workup

  1. additionwas treated in a similar manner to that of Example 14-(7)
  2. washThe resultant residue was washed with n-hexane
  3. customdried

Sources & evidence

ORD record
ord-e2fe17eea1e04167b2c887aacd398dcf
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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