HCID 20513471, compound → 3-n-Propyl-7-(2-chlorophenoxy)-2,3-dihydrobenzofuran-2-one

HRID 1164052Notes

Reaction equation

HRID 1164052 reaction equation
CO[C:3]1[C:8]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[Cl:16])=[CH:7][CH:6]=[CH:5][C:4]=1[CH:17]([CH2:21][CH2:22][CH3:23])[C:18]([OH:20])=[O:19]>C(OC(=O)C)(=O)C.I>[CH2:21]([CH:17]1[C:4]2[CH:5]=[CH:6][CH:7]=[C:8]([O:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[Cl:16])[C:3]=2[O:19][C:18]1=[O:20])[CH2:22][CH3:23]

Participants

4

Reactant 1

HCID 20513471HCID 20513471, compound

Product 1

HCID 130667123-n-Propyl-7-(2-chlorophenoxy)-2,3-dihydrobenzofuran-2-oneYield 43.7%

Reagents, catalysts & solvents 2

HCID 7918Acetic AnhydrideSolventHCID 24841Hydrogen iodideSolvent

Procedure

A solution of 2-[2-methoxy-3-(2-chlorophenoxy)phenyl]valeric acid (3.8 g) in acetic anhydride (10 ml) and hydriodic acid (55-58%, 20 ml) were treated in a similar manner to that of Example 14-(8) to give 3-n-propyl-7-(2-chlorophenoxy)-2,3-dihydrobenzofuran-2-one (1.5 g). mp 51°-53° C.

Sources & evidence

ORD record
ord-41b3aa1687bd45b698ccf9510174dcc0
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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