HCID 20513454, compound → HCID 13066713, compound

Participants

Reaction Steps

A solution of 2-[2-methoxy-3-(2-fluorophenoxy)phenyl]acetic acid (5.4 g) in acetic anhydride (15 ml) and hydriodic acid (55-58%, 30 ml) were treated in a similar manner to that of Example 10-(7). The resultant oily residue, i.e. 2-[2-hydroxy-3-(2-fluorophenoxy)phenyl]acetic acid was treated with acetic anhydride (10 ml) in a similar manner to that of Example 10-(7). The resultant crystalline residue was recrystallized from ethanol to give 7-(2-fluorophenoxy)-2,3-dihydrobenzofuran-2-one (3 g). mp 82°-84° C.

Provenance & Evidence