HCID 20513454, compound → HCID 13066713, compound

HRID 1164054Notes

Reaction equation

HRID 1164054 reaction equation
CO[C:3]1[C:8]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[F:16])=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:17][C:18]([OH:20])=[O:19].OC1C(OC2C=CC=CC=2F)=CC=CC=1CC(O)=O>C(OC(=O)C)(=O)C.I>[F:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[O:9][C:8]1[C:3]2[O:20][C:18](=[O:19])[CH2:17][C:4]=2[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 20513454HCID 20513454, compoundHCID 20513483HCID 20513483, compound

Product 1

HCID 13066713HCID 13066713, compoundYield 62.8%

Reagents, catalysts & solvents 2

HCID 7918Acetic AnhydrideSolvent2×HCID 24841Hydrogen iodideSolvent

Procedure

A solution of 2-[2-methoxy-3-(2-fluorophenoxy)phenyl]acetic acid (5.4 g) in acetic anhydride (15 ml) and hydriodic acid (55-58%, 30 ml) were treated in a similar manner to that of Example 10-(7). The resultant oily residue, i.e. 2-[2-hydroxy-3-(2-fluorophenoxy)phenyl]acetic acid was treated with acetic anhydride (10 ml) in a similar manner to that of Example 10-(7). The resultant crystalline residue was recrystallized from ethanol to give 7-(2-fluorophenoxy)-2,3-dihydrobenzofuran-2-one (3 g). mp 82°-84° C.

Workup

  1. customThe resultant crystalline residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-8bf5a8e182184d448af8405b4bb20927
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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