反应详情

A solution of 2-(2-methoxy-3-phenoxyphenyl)acetic acid (2.1 g) in acetic anhydride (10 ml) and hydriodic acid (55-58%, 20 ml) were treated in a similar manner to that of Example 10-(7). To the resultant oily residue containing 2-(2-hydroxy-3-phenoxyphenyl)acetic acid was added acetic anhydride (5 ml), and the mixture was refluxed under heating for 30 minutes and then evaporated. The oily residue (1.5 g) was purified by column chromatography (silica gel, benzene) and crystallization from ethanol to give 7-phenoxy-2,3-dihydrobenzofuran-2-one (950 mg). mp 60°-61° C.

1. temperaturethe mixture was refluxed
2. temperatureunder heating for 30 minutes
3. customevaporated
4. customThe oily residue (1.5 g) was purified by column chromatography (silica gel, benzene) and crystallization from ethanol