Methyl iodide → HCID 20513497, compound

HRID 1164072Notes

Reaction equation

HRID 1164072 reaction equation
[H-].[Na+].[C:3]([CH:5]([C:11]1[CH:16]=[C:15]([O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[Cl:24])[CH:14]=[CH:13][C:12]=1[O:25][CH3:26])[C:6]([O:8][CH2:9][CH3:10])=[O:7])#[N:4].[CH3:27]I>>[C:3]([C:5]([C:11]1[CH:16]=[C:15]([O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[Cl:24])[CH:14]=[CH:13][C:12]=1[O:25][CH3:26])([CH3:27])[C:6]([O:8][CH2:9][CH3:10])=[O:7])#[N:4]

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 20513411HCID 20513411, compound

Product 1

HCID 20513497HCID 20513497, compoundYield 92.7%

Procedure

Sodium hydride (65.5%, 665 mg), ethyl 2-cyano-2-[2-methoxy-5-(2-chlorophenoxy)phenyl]acetate (5.7 g) and methyl iodide (3.55 g) were treated in a similar manner to that of Example 10-(5) to give oily ethyl 2-cyano-2-[2-methoxy-5-(2-chlorophenoxy)phenyl]propionate (5.5 g).

Sources & evidence

ORD record
ord-fe2cb2afd30a4d48b798f89ca46f34c0
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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