HCID 20513406, compound → HCID 20513495, compound

HRID 1164074Notes

Reaction equation

HRID 1164074 reaction equation
CO[C:3]1[CH:8]=[CH:7][C:6]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[Cl:16])=[CH:5][C:4]=1[CH:17]([CH3:21])[C:18]([OH:20])=[O:19]>C(OC(=O)C)(=O)C.I>[CH3:21][CH:17]1[C:4]2[CH:5]=[C:6]([O:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[Cl:16])[CH:7]=[CH:8][C:3]=2[O:19][C:18]1=[O:20]

Participants

4

Reactant 1

HCID 20513406HCID 20513406, compound

Product 1

HCID 20513495HCID 20513495, compoundYield 73.3%

Reagents, catalysts & solvents 2

HCID 7918Acetic AnhydrideSolventHCID 24841Hydrogen iodideSolvent

Procedure

A solution of 2-[2-methoxy-5-(2-chlorophenoxy)phenyl]propionic acid (3.2 g) in acetic anhydride (10 ml) and hydriodic acid (55-58%, 20 ml) were treated in a similar manner to that of Example 14-(8) to give oily 3-methyl-5-(2-chlorophenoxy)2,3-dihydrobenzofuran-2-one (2.1 g).

Sources & evidence

ORD record
ord-de16ec38ae1a4464af48152c6233636d
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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